کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10586120 | 981385 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel antimicrobial peptides that exhibit activity against select agents and other drug resistant bacteria
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کلمات کلیدی
PoPC1-palmitoyl-2-oleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (sodium salt)βAlaPOPG6-aminohexanoic acidDPROICTICITCAMP1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine - 1-پالمیتویل-2-اولئویل-اسن-گلیسرو-3-فسفوشولینFpA - FPAAhx - آهکسMRSA - استافیلوکوک اورئوس مقاوم به متی سیلین یا MRSA large unilamellar vesicles - بزرگ کیسه های بدون انعطاف پذیرIn vitro activity - فعالیت in vitroLUV - لووAntimicrobial peptide - پپتیدهای ضدمیکروبیAntimicrobial peptides - پپتیدهای پادمیکرب یا آنتیمایکروبیال پپتایدIsothermal titration calorimetry - کالری سنجی تیتاسیون ایزوترمالGABA - گابا
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
One of the greatest challenges facing modern medicine is the evolution of drug resistant strains of bacteria. In addition to traditional methods of exposure to traditional bacterial organisms there is a growing concerned of the use of bacteria as bio-terrorism agents. To counter the evolution of drug resistant and potential bio-terrorism bacterial agents new antibiotic drugs must be developed. One potential source of new therapeutic agents that act via a novel mechanism of action are natural and synthetic antimicrobial peptides (AMPs). In our laboratories we have developed a series of AMPs incorporating the un-natural amino acids Tic-Oic to impart organism selectivity and potency while increasing metabolic stability. Herein the in vitro activity of these peptides, including ten new compounds, against eight potential bio-terrorism bacterial agents and three other bacterial strains is presented and discussed. These peptides exhibit a wide range of organism potency and selectivity. Calcein fluorescence leakage and circular dichroism studies were conducted to confirm that these peptides interact with zwitterionic and anionic liposomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 14, 15 July 2010, Pages 5137-5147
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 14, 15 July 2010, Pages 5137-5147
نویسندگان
Divakaramenon Venugopal, David Klapper, Antoine H. Srouji, Jayendra B. Bhonsle, Richard Borschel, Allen Mueller, Amanda L. Russell, Brittany C. Williams, Rickey P. Hicks,