Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-кB and AP-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anti-cancer agents

A series of 2-(2,3-disubstituted-thiophen-5-yl)-3H-quinazolin-4-one analogs was designed, synthesized and evaluated for its inhibitory activity towards transcription factors NF-κB and AP-1 mediated transcriptional activation. Their possible utilization as anti-inflammatory and anti-cancer agent has been discussed.