Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors

A series of new 1H-pyrrolopyrimidine-2,4-diones were prepared and evaluated for their affinities at α1-adrenoceptors and 5-HT1A receptors. Binding data were used in computational studies aimed at clarifying molecular requirements for the design of high-selective ligands.