Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP)

Summary of structural features influencing the inhibition of BCRP by flavonoids. Plus-circles indicate the positive contribution of structural elements to anti-BCRP activity. Minus-circles illustrate the negative impact on inhibitory potency. Results are based on data from the 3D QSAR approaches of the present study as well as the findings from 2D QSAR analyses of data taken from literature.