Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide libraries

Peptide ligands were identified for the medicinally important galectins by screening on-bead with a synthetic solid-phase peptide library and by screening with a phage-display library. The first method yielded sequences binding at or near the carbohydrate-binding site while the latter yielded a sequence binding at a different site.