Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents

The bioassay tests showed that compounds 6e and 6f exhibited certain effective against gastric SGC-7901 cell with the IC50 values were 22.28 ± 6.26 and 18.45 ± 2.79 μg/mL, respectively. Compound 6e can strongly inhibit telomerase with IC50 value of 0.8 ± 0.07 μg/mL. The docking simulation result shows that some 2-chloro-pyridine containing flavone (6e) can combine well with the telomerase active site may use as potential telomerase inhibitors.