Hypolipidemic and antioxidant activities of polysaccharides from Rosae Laevigatae Fructus in rats

► Two polysaccharides (RLP-1 and RLP-2) were purified from Rosae Laevigatae Fructus. ► RLP-1 was composed of Xyl, Man and Gal while RLP-2 was only composed of Glu. ► RLP-1 ameliorated high fat diet-induced hyperlipidemia in rats but RLP-2 could not. ► RLP-1 improved lipid profiles through regulating PPAR-γ/LPL pathway.