Laccase-assisted formation of bioactive chitosan/gelatin hydrogel stabilized with plant polyphenols

► Laccase-assisted formation of chitosan/gelatin hydrogel with plant phenolics. ► Mechanical properties of the hydrogel are function of the reaction time. ► Stable under physiological conditions and resistant to lysozyme degradation. ► Capacity to inhibit myeloperoxidase and collagenase activities. ► Hydrogel antibacterial activity against P. aeruginosa and S. aureus.