Diversity in the supramolecular interactions of 5,6-dichloro-2-(trifluoromethyl)-1H-benzimidazole with modified cyclodextrins: Implications for physicochemical properties and antiparasitic activity

► Three modified cyclodextrins (CDs) form complexes with a benzimidazole derivative. ► NMR data reveal different modes of interaction between benzimidazole and CDs. ► Novel partial-inclusion complex was formed with hydroxypropyl-β-CD. ► ESI-mass spectrometry confirmed the stoichiometry of the complexes. ► Methylated CD inclusion complex antiparasitic profile supersede free benzimidazole.