Mechanical grinding effect on thermodynamics and inclusion efficiency of loratadine-cyclodextrin inclusion complex formation

► Inclusion efficiency of LOR into β-CD or HP-β-CD was correlated with LOR crystallinity and grinding time. ► Longer grinding time induced more loss of LOR crystallinity and caused higher inclusion complex formed. ► The mechanism of inclusion formation for LOR into β-CD or HP-β-CD was proposed by three steps with mechanical grinding process.