کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10602571 | 982388 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Detailed characterization of an injectable hyaluronic acid-polyaspartylhydrazide hydrogel for protein delivery
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Detailed characterization of an injectable hyaluronic acid-polyaspartylhydrazide hydrogel for protein delivery Detailed characterization of an injectable hyaluronic acid-polyaspartylhydrazide hydrogel for protein delivery](/preview/png/10602571.png)
چکیده انگلیسی
The authors previously reported an injectable crosslinking hydrogel system based on the reaction between a hyaluronic acid (HA) derivative and α,β-polyaspartylhydrazide (PAHy). The HA derivative carrying dialdehyde (HAALD) was shown to react fast (30 s) with PAHy under mild conditions to produce a hydrazone conjugated hydrogel, without addition of crosslinker or catalyst. The present paper completes the initial research by examining the properties of the hydrogels in detail. HAALD-PAHy hydrogels were synthesized in PBSA solution and characterized by different methods including gel content and swelling, Fourier transformed infrared spectra, thermogravimetric analysis, in vitro degradation and biocompatibility experiments. A scanning electron microscope viewed the interior morphology of HAALD-PAHy gel whose porous three-dimensional structure enabled it to efficiently encapsulate the proteins. Sustained and stable protein release from the HAALD-PAHy hydrogel was observed during in vitro delivery experiments and exhibited its potentially high application prospect in the field of protein drug delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 85, Issue 4, 1 July 2011, Pages 717-725
Journal: Carbohydrate Polymers - Volume 85, Issue 4, 1 July 2011, Pages 717-725
نویسندگان
Rui Zhang, ZhiBing Huang, MingYuan Xue, Jing Yang, TianWei Tan,