کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10603092 | 982436 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solid lipid nanoparticles modified with chitosan oligosaccharides for the controlled release of doxorubicin
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Solid lipid nanoparticles (SLN) modified with chitosan oligosaccharide was prepared by solvent diffusion method and subsequent ionic interaction. Using doxorubicin as a model drug, the effects of amount and molecular weight of chitosan oligosaccharide, and its crosslink degree by glutaraldehyde on the physicochemical properties of nanoparticles were investigated. After modification with chitosan oligosaccharide, the zeta potential of nanoparticles changed from about â20Â mV to above 30Â mV, and the drug loading could be improved from 6.76% to 22.3%. In vitro drug release tests showed the burst release of SLN could be significantly reduced by the chitosan oligosaccharide modification, and the release rate could be controlled by changing the molecular weight of chitosan oligosaccharide and the crosslink degree. In vitro antitumor activity tests indicated the SLN could mediate the cellular internalization of doxorubicin, and the chitosan oligosaccharide modification and crosslink could further improve the cellular uptake and cytotoxicity of doxorubicin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 84, Issue 4, 2 April 2011, Pages 1357-1364
Journal: Carbohydrate Polymers - Volume 84, Issue 4, 2 April 2011, Pages 1357-1364
نویسندگان
Xiao-Ying Ying, Dan Cui, Lian Yu, Yong-Zhong Du,