Effects of drug chemistry on the dispersion and release behaviour of polyurethane organosilicate nanocomposites

► Silicate dispersion of nanocomposites can be disrupted by the addition of a drug. ► Component interactions within a nanocomposite system alters the release profile. ► Interactions were related to the physical and chemical properties of the drug. ► Positively charged drugs can potentially displace modifiers from the clay surface. ► Drug release can be promoted if the added drug has repulsive nature with the clay.