pH- and temperature-responsive poly(aspartic acid)-l-poly(N-isopropylacrylamide) conetwork hydrogel

► Succinimide rings opened conveniently by nucleophilic agents such as alkyl amines. ► Swelling degree of PASP-l-PNIPAAm exhibited a significant change around pH = 4.1. ► Large difference was observed in swelling degree as a function of temperature. ► Release profile of DiclofenacNa was different in simulated gastric and intestinal fluid.