کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10691286 1019591 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Theoretical Evaluation of the Acoustic Field in an Ultrasonic Bioreactor
ترجمه فارسی عنوان
ارزیابی تئوری میدان آکوستیک در بیوراکتور آلتراسونیک
کلمات کلیدی
سونوگرافی، بیو آکوستیک، مکانیک انتقال، مهندسی بافت، روش حجم محدود روش طیفی، نظریه بیوت،
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم آکوستیک و فرا صوت
چکیده انگلیسی
Ultrasound-assisted bioreactors that provide mechanical conditioning to cells have broad applicability in tissue engineering, but biological experiments with ultrasound are very sensitive to environmental conditions. A mathematical model was developed to complement experimental measurements, as well as to describe ultrasonic fields existing in regions where measurements are impossible, specifically, within microporous tissue engineering scaffolds. The model uniquely combines Biot theory to predict the ultrasonic field in the scaffold with an electromechanical transducer model to couple the mechanical stimulation experienced by cells to the external electrical input. In the specific example examined here, cells immobilized on scaffolds are subjected to different forms of ultrasonic stimulation due to the formation of standing wave fields and vertical high-pressure bands. The model confirms the sensitivity of the supplied acoustic power to the liquid level in sonobioreactors and identifies the input electrical impedance as a method of detecting resonance effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 41, Issue 6, June 2015, Pages 1766-1778
نویسندگان
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