کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10691895 | 1019613 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In Vitro Localized Release of Thermosensitive Liposomes with Ultrasound-Induced Hyperthermia
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In Vitro Localized Release of Thermosensitive Liposomes with Ultrasound-Induced Hyperthermia In Vitro Localized Release of Thermosensitive Liposomes with Ultrasound-Induced Hyperthermia](/preview/png/10691895.png)
چکیده انگلیسی
Localized drug delivery with ultrasound-induced hyperthermia can enhance the therapeutic index of chemotherapeutic drugs by improving efficacy and reducing systemic toxicity. A novel in vitro method for the activation of drug-loaded thermosensitive liposomes is described. In particular, a dual-compartment, acoustically transparent container is used in which thermosensitive liposomes suspended in cell culture medium are immersed in a thermally absorptive medium, glycerol. Hyperthermia is induced with ultrasound in the glycerol, which in turn heats the culture medium by thermal conduction. The method approximately mimics the in vivo scenario of thermosensitive liposomes collected in the interstitial spaces of tumors, where ultrasound induces hyperthermia in the tumor tissue, which in turn heats the thermosensitive liposomes by conduction and induces release of the encapsulated drug. The acoustic conditions for the desired hyperthermia are derived theoretically and validated experimentally. Eighty percent release of doxorubicin from thermosensitive liposomes is achieved.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 39, Issue 11, November 2013, Pages 2011-2020
Journal: Ultrasound in Medicine & Biology - Volume 39, Issue 11, November 2013, Pages 2011-2020
نویسندگان
Christophoros Mannaris, Eleni Efthymiou, Marie-Edith Meyre, Michalakis A. Averkiou,