کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10738030 | 1046678 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of surgical trauma-enhanced peritoneal dissemination of tumor cells by human catalase derivatives in mice
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کلمات کلیدی
ECMPAI-1TGF-β1ABPhuman catalaseTissue necrosis factor-αGAPDHMDAICAM-1RT-PCRROS - ROSTransforming growth factor-β1 - تبدیل فاکتور رشد β1Free radicals - رادیکال آزادcircular dichroism - رنگ تابی دورانیSurgical trauma - ضربه جراحیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Vascular Endothelium Growth Factor - فاکتور رشد اندوتلیوم عروقیTNF-α - فاکتور نکروز توموری آلفاExtracellular matrix - ماتریکس خارج سلولیmalondialdehyde - مالون دی آلدهیدTumor metastasis - متاستاز تومورPlasminogen activator inhibitor-1 - مهار کننده فعال کننده پلاسمینوژن-1intracellular adhesion molecule-1 - مولکول چسبندگی داخل سلولی -1reverse transcription–polymerase chain reaction - واکنش زنجیره ای رونویسی-پلیمراز معکوسglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژنازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Surgical trauma, which is inevitably associated with the surgical removal of cancer, has been reported to accelerate tumor metastasis. The close association of reactive oxygen species with the trauma and tumor metastasis supports the possibility of using antioxidants for the inhibition of metastasis. To inhibit surgical trauma-enhanced peritoneal dissemination, human catalase (hCAT) derivatives, i.e., hCAT-nona-arginine peptide (hCAT-R9) and hCAT-albumin-binding peptide (hCAT-ABP), were designed to increase the retention time of the antioxidant enzyme in the abdominal cavity after intraperitoneal administration. Both 125I-labeled derivatives showed significantly prolonged retention in the cavity compared to 125I-hCAT. Cauterization of the cecum of mice with a hot iron, an experimental model of surgical trauma, induced abdominal adhesions. In addition, cauterization followed by colon26 tumor cell inoculation increased lipid peroxidation in the cecum and mRNA expression of molecules associated with tissue repair/adhesion and inflammation in the peritoneum. hCAT derivatives significantly suppressed the increased mRNA expression. The cauterization also increased the number of tumor cells in the abdominal organs, and the number was significantly reduced by hCAT-R9 or hCAT-ABP. These results indicate that hCAT-R9 and hCAT-ABP, both of which have a long retention time in the peritoneal cavity, can be effective at inhibiting surgery-induced peritoneal metastasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 51, Issue 3, 1 August 2011, Pages 773-779
Journal: Free Radical Biology and Medicine - Volume 51, Issue 3, 1 August 2011, Pages 773-779
نویسندگان
Chika Nishizaki, Makiya Nishikawa, Tomoya Yata, Toshiyuki Yamada, Yuki Takahashi, Masahide Oku, Hiroya Yurimoto, Yasuyoshi Sakai, Kenji Nakanishi, Yoshinobu Takakura,