Calorie restriction increases cerebral mitochondrial respiratory capacity in a NO•-mediated mechanism: Impact on neuronal survival

► Calorie restriction (CR) increases eNOS, nNOS, and mitochondrial content in brain. ► Serum from CR animals increases nNOS and NO
- in neuronal cultures. ► CR serum enhances mitochondrial biogenesis and respiratory rates in neurons. ► CR serum effects are inhibited by L-NAME and mimicked by the NO
- donor SNAP. ► CR serum and SNAP increase neuronal survival.