Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis

► Oxidative stress and inflammation are elevated in renal tissues after rhabdomyolysis. ► Antioxidants bisphenol/ascorbate synergize to inhibit renal oxidation/inflammation. ► Not all markers of acute kidney injury improved indicating that renal dysfunction persists. ► Lipid- and water-soluble antioxidants differ in their effect on rhabdomyolysis.