کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10739057 | 1046858 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential sensitization of cancer cells to doxorubicin by DHA: A role for lipoperoxidation
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کلمات کلیدی
GSSGEPAP-gpPBSMDRGSHDMSO - DMSOP-glycoprotein - P-گلیکوپروتئینROS - ROSAnthracycline - آنتراسیکلینEicosapentaenoic acid - اسید ایکوزاپنتانوئیکdocosahexaenoic acid - اسید داکوزاگزوائونیکPolyunsaturated fatty acid - اسید چرب غیر اشباعPUFA - اسید چرب چند غیراشباعDrug accumulation - تجمع مواد مخدرOxidative stress - تنش اکسیداتیوDHA - دوکوساهگزائنوئیک اسیدDimethyl sulfoxide - دیمتیل سولفواکسیدBreast cancer - سرطان پستانPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریMultidrug resistance - مقاومت چند داروییglutathione (oxidized) - گلوتاتیون (اکسید شده)Glutathione (reduced) - گلوتاتیون (کاهش یافته)Reactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential sensitization of cancer cells to doxorubicin by DHA: A role for lipoperoxidation Differential sensitization of cancer cells to doxorubicin by DHA: A role for lipoperoxidation](/preview/png/10739057.png)
چکیده انگلیسی
Polyunsaturated fatty acids have been reported to enhance the cytotoxic activity of several anticancer drugs. In the present study, we observed that doxorubicin chemosensitization of breast cancer cell lines by docosahexaenoic acid (DHA, a long-chain Ï-3 polyunsaturated fatty acid) was cell-line selective, affecting MDA-MB-231 and MCF-7dox (a doxorubicin-resistant cell line) but not the parental MCF-7 cell line. DHA supplementation led to an increase in membrane phospholipid DHA level, but did not induce changes in intracellular [14C]doxorubicin accumulation. In MDA-MB-231, doxorubicin efficacy enhancement by DHA was linked to an increase in malondialdehyde level, a final product of lipid peroxidation. DHA elicited by itself a 3.7-fold malondialdehyde level increase, additive to that induced by doxorubicin. Addition of doxorubicin to DHA further increased the glutathione level, indicative of the generation of an oxidative stress. In contrast to MDA-MB-231, doxorubicin did not increase the malondialdehyde level in MCF-7, although DHA induced lipid peroxidation. Therefore in MCF-7, lipid peroxidation induced by DHA itself was not sufficient to trigger an oxidative stress and to subsequently increase sensitivity to doxorubicin. These data indicate that the differential effect of DHA among cells on drug toxicity results from a differential oxidative response to doxorubicin. Chemosensitization through fatty acids appears as a new promising adjuvant therapeutic paradigm, since Ï-3 fatty acids are physiological molecules found in food and are nontoxic in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 39, Issue 6, 15 September 2005, Pages 742-751
Journal: Free Radical Biology and Medicine - Volume 39, Issue 6, 15 September 2005, Pages 742-751
نویسندگان
Karine Mahéo, Sophie Vibet, Jean Paul Steghens, Caroline Dartigeas, Magali Lehman, Philippe Bougnoux, Jacques Goré,