کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10739348 | 1046872 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long-term melatonin or 17β-estradiol supplementation alleviates oxidative stress in ovariectomized adult rats
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کلمات کلیدی
PBSTBARSDTNBOVXovariectomizedMOPS4-morpholinepropanesulfonic acid - 4-مورفولین پروپان سولفونیک اسیدAlzheimer's disease - بیماری آلزایمرOxidative stress - تنش اکسیداتیوApoptosis - خزان یاختهایSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریMelatonin - ملاتونینthiobarbituric acid-reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکERT - هستند
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Melatonin is an endogenously generated potent antioxidant. Our previous results indicated that melatonin improved learning and memory deficits in the transgenic mouse model of Alzheimer's disease (AD) and ovariectomized (OVX) rats by improving cholinergic nerve system dysfunction, preventing apoptosis. In this study we aim to investigate the antioxidative effects of melatonin or estradiol in the brains of ovariectomized rats. OVX Sprague-Dawley rats received daily injections of melatonin (5, 10, or 20 mg/kg), 17β-estradiol (80 μg/kg), or sesame oil for 16 weeks. We found an increase in brain mitochondrial thiobarbituric acid-reactive substances (TBARS) levels, a decrease in mitochondrial glutathione (GSH) content as well as mitochondrial superoxide dismutase (SOD) activity and upregulation of the apoptotic-related factors, such as Bax, Caspase-3, and Prostate apoptosis response-4 (Par-4) in the frontal cortex of OVX rats. In addition to oxidative stress, OVX also caused decreased activities of mitochondrial respiration complex I and complex IV, which implicated mitochondrial dysfunction. Melatonin or 17β-estradiol antagonized the detrimental effects induced by OVX. Furthermore, immunohistochemistry results revealed that the abnormal upregulation of the apoptotic related factor such as Bax, Caspase-3, and (Par-4) greatly reduced expression after melatonin or 17β-estradiol supplement action. These findings demonstrate the important effects of melatonin or 17β-estradiol on postmenopausal neuropathy and support the potential application of melatonin in the treatment of dementia in postmenopausal women. Early, long-term melatonin application is a promising strategy which could potentially be applied in a clinical setting.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 39, Issue 2, 15 July 2005, Pages 195-204
Journal: Free Radical Biology and Medicine - Volume 39, Issue 2, 15 July 2005, Pages 195-204
نویسندگان
Zheng Feng, Jun-tian Zhang,