کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10749301 | 1050287 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Probiotic-derived polyphosphate improves the intestinal barrier function through the caveolin-dependent endocytic pathway
ترجمه فارسی عنوان
پلی فسفات مشتق شده از پروبیوتیک عملکردهای مانع روده را از طریق مسیر اندوسیتیک وابسته به کاوئولین بهبود می بخشد
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
پروبیوتیک ها، پلی فسفات تعامل میزبان-پروبیوتیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Probiotics exhibit beneficial functions for host homeostasis maintenance. We herein investigated the mechanism by which Lactobacillus brevis-derived poly P exhibited a beneficial function. Immunostaining indicated that poly P was captured in the plasma membrane via integrin β1 in Caco2/bbe cells. The uptake of poly P was reduced by the inhibition of integrin β1 as well as caveolin-1, a major component of lipid rafts. The function of poly P, including the induction of HSP27 and enhancement of the intestinal barrier function, was suppressed by the inhibition of caveolin-1, illustrating that the function of poly P was mediated by the endocytic pathway. High-throughput sequencing revealed that poly P induced tumor necrosis factor alpha-induced protein 3, which contributes to cytoprotection, including upregulation of the intestinal barrier function. The present study demonstrates a novel host-probiotic interaction through the uptake of bacterial substance into host cells, which is distinct from pattern recognition receptor pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 467, Issue 3, 20 November 2015, Pages 541-548
Journal: Biochemical and Biophysical Research Communications - Volume 467, Issue 3, 20 November 2015, Pages 541-548
نویسندگان
Kazuyuki Tanaka, Mikihiro Fujiya, Hiroaki Konishi, Nobuhiro Ueno, Shin Kashima, Junpei Sasajima, Kentaro Moriichi, Katsuya Ikuta, Hiroki Tanabe, Yutaka Kohgo,