کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10749535 1050292 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Productive folding of a tethered protein in the chaperonin GroEL-GroES cage
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Productive folding of a tethered protein in the chaperonin GroEL-GroES cage
چکیده انگلیسی
Many proteins in bacterial cells fold in the chaperonin cage made of the central cavity of GroEL capped by GroES. Recent studies indicate that the polypeptide in the cage spends the most time as a state tethered dynamically to the GroEL/GroES interface region, in which folding occurs in the polypeptide segments away from the tethered site (F. Motojima & M. Yoshida, EMBO J. (2010) 29, 4008-4019). In support of this, we show here that a polypeptide in the cage tethered covalently to an appropriate site in the GroEL/GroES interface region can fold to a near-native structure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 466, Issue 1, 9 October 2015, Pages 72-75
نویسندگان
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