کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10751015 1050306 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929
چکیده انگلیسی
Clnk, as a third member of the Blnk/SLP-76 adapter family, is involved in the positive regulation of immunoreceptor signaling. Here we provide findings that Clnk may be is required for TNF induced cell death, it functions downstream of RIP3 and promotes TNF- induced ROS generation and MLKL tetramer formation and subsequent necrosis of L929 cells. Therefore, Clnk, as an adaptor protein, may take part in the other cellular processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 463, Issue 3, 31 July 2015, Pages 275-279
نویسندگان
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