Keywords: Hyperoxic acute lung injury; Necroptosis; Reactive oxygen species; RIP1; RIP3; MLKL;
مقالات ISI (ترجمه نشده)
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Keywords: AKP; alkaline phosphatase; ALA; α-linolenic acid; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BW; body weight; COX2; cyclooxygenase 2; DAMP; damage-associated molecular pattern; ERK1/2; extracellular signal-regulated kinase 1/2; GGT;
Keywords: APC; antigen-presenting cell; ATG; autophagy-related gene; ATP; adenosine triphosphate; ANXA1; annexin A1; BECN1; beclin-1; CD; cluster of differentiation; CRT; calreticulin; CTL; cytotoxic T lymphocyte; (CTLA)-4; CTL associated protein-4; DAMP; danger-as
Keywords: Status epilepticus; Necroptosis; Brain injury; RIP3; MLKL; Cognitive impairment;
Keywords: TriZol Reagent; buffered 10% formalin; ethanol; xylol; paraffin; hematoxylin and eosin (HE); phosphate buffer (pH 6.5); Griess solution (0.1% N-1-naphthyl-tilediamine, 1% sulfanilamide in 5% H3PO4); saline Triton X-100 0.1%, TMB 18.4âmM; dimethylformami
Keywords: TNBC; triple negative breast cancer; ROS; reactive oxygen species; H2DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; MTT; 3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2H-tetrazolium bromide; CI value; combination index value; DXR; doxorubicin; 3-MA; 3
Keywords: ABIN; A20 binding and inhibitor of NF-κB; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; Atg; autophagy-related gene; C9ORF72; chromosome 9 open reading frame 72; CC; coiled-coil; cIAP; cellular inhibitor of apoptosis protein; CYLD; cylin
Keywords: Necroptosis; Smac mimetic; Cell death; Pancreatic carcinoma; IAP proteins; cIAP; cellular IAP; FADD; Fas-associated protein with death domain; FCS; fetal calf serum; GAPDH; anti-glyceraldehyde 3-phosphate dehydrogenase; IAP; inhibitor of apoptosis; MLKL;
Keywords: Breast cancer; Necrosis; Apoptosis; Cytotoxicity; Cancer therapeutics; HMA; 5-(N,N-hexamethylene) amiloride; DCFH-DA; carboxy-2â²,7â²-dichloro-dihydro-fluorescein diacetate; ROS; reactive oxygen species; PI3K; phosphatidylinositol-3 kinase; PKB; protein
Keywords: apoptosis; ferroptosis; mitochondrial permeability transition; MLKL; programmed cell death; regulated cell death; RIP1; RIPK1; RIP3; RIPK3;
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; Apaf-1; apoptotic protease activating factor 1; CAD; caspase-activation DNase; cyt c; cytochrome c; Cy; cyclophilin; Drp-1; dynamin-related protein 1; ENDO; endonuclease; AIF; apoptosis-inducing
Keywords: Celastrol; Necroptosis; MLKL; RIP3; Ulcerative colitis;
Keywords: PCD; programmed cell death; FADD; fas-associated protein with death domain; FLIP; FLICE-inhibitory protein; NLRP3; (NACHT, LRR and PYD domain-containing protein3); cIAP; cellular inhibitor of apotosis protein; Z-YVAD-FMK; benzyloxycarbonyl-Tyr-Val-Ala-Asp
Keywords: 4-PBA; 4-phenylbutyrate; CC3; cleaved Caspase-3; CXCR4; chemokine (C-X-C motif) receptor 4; DMEM; Dulbecco's modified Eagle medium; EDTA; ethylenediaminetetraacetic acid; EM; electronic microscopic; ER; endoplasmic reticulum; FBS; fetal bovine serum; GR
Keywords: AIF; apoptosis-inducing factor; ANT; adenine nucleotide translocase; CsA; cyclosporin A; CYPD; cyclophilin D; ÎÏm; mitochondrial transmembrane potential; Fer-1; ferrostatin-1; MAMP; microbe-associated molecular pattern; MLKL; mixed lineage kinase domain
Keywords: Apoptosis; Necrosis; Necroptosis; Necrosome; DAMP; Viral Hepatitis; NASH; Clinical Trial; Hepatocellular Carcinoma; Alcoholic Liver Disease; DILI; Caspases; RIP3; RIP Kinases; ALD; alcoholic liver disease; ALT; alanine aminotransferase; AST; aspartate ami
Necroptosis in 3-chloro-1, 2-propanediol (3-MCPD)-dipalmitate-induced acute kidney injury in vivo and its repression by miR-223-3p
Keywords: 3-MCPD; 3-chloro-1,2-propanediol; 3â²UTR; 3â² un-translated region; AKI; acute kidney injury; BMD10; Benchmark doses; BMDL10; BMD Lower Confidence Limit; BW; body weight; CXCl; chemokine (C-X-C motif) ligand; DE; differentially expressed; DR6; death rec
The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D
Keywords: Allergy; asthma; Staphylococcus aureus; sensitization; serine protease; AECII; Airway epithelial cell type II; APC; Allophycocyanin; BALF; Bronchoalveolar lavage fluid; DC; Dendritic cells; DMEM; Dulbecco modified Eagle medium; FACS; Fluorescence-activate
A rare variant in MLKL confers susceptibility to ApoE É4-negative Alzheimer's disease in Hong Kong Chinese population
Keywords: Late-onset Alzheimer's disease; ApoE É4-negative; Whole exome sequencing; MLKL;
High-mobility group box 1 protein-mediated necroptosis contributes to dasatinib-induced cardiotoxicity
Keywords: HMGB1; high mobility group box 1; CML; chronic myelogenous leukemia; Ph+ALL; Philadelphia chromosome positive acute lymphoblastic leukemia; RIP1; receptor-interacting protein kinase 1; RIP3; receptor-interacting protein kinase 3; MLKL; mixed lineage kinas
Type I Immune Response Induces Keratinocyte Necroptosis and Is Associated with Interface Dermatitis
Keywords: ID; interface dermatitis; ISD; inflammatory skin disease; LE; lupus erythematosus; LP; lichen planus; MLKL; mixed lineage kinase domain like pseudokinase; RIP3; receptor-interacting-protein-kinase 3; ShRNA; small hairpin RNA; TCS; T-cell supernatant; Th;
Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation
Keywords: 24(S)-hydroxycholesterol; Cell death; Tοc; Tοc3; CaMKII; RIPK1; ACAT1; acyl-CoA:cholesterol acyltransferase 1; 24S-OHC; 24(S)-hydroxycholesterol; atRA; all-trans-retinoic acid; α-Toc; α-tocopherol; α-Toc3; α-tocotrienol; BBB; blood-brain barrier (
PDZK1 in leukocytes protects against cellular apoptosis and necrotic core development in atherosclerotic plaques in high fat diet fed ldl receptor deficient mice
Keywords: Apoptosis; Atherosclerosis; HDL; Macrophage; Signaling; BMT; bone marrow transplantation; CC3; cleaved caspase 3; CHOP; CEBP-homologous Protein; DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride; ER; endoplasmic reticulum; GRP; glucose regulated prote
Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia
Keywords: SFN; sulforaphane; LPS; lipopolysaccharide; NF-κB; nuclear transcription factor-kappa B; TNF-α; tumor necrosis factor-alpha; IL-6; interleukin-6; IL-1β; interleukin-1 beta; iNOS; inducible NO synthase; MLKL; mixed lineage kinase domain like; PPP; pento
Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke
Keywords: BSA; bovine serum albumin; CBF; cerebral blood flow; CSPGs; chondroitin sulfate proteoglycans; DTIO; 5-(3â²,5â²-dimethoxybenzal)-2-thio-imidazole-4-ketone; ELISA; enzyme-linked immunosorbent assay; GFAP; glial fibrillary acidic protein; HT22; hippocampa
JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice
Keywords: Tumor Microenvironment; Drug Development; Targeted Therapy; Pancreas; AE; anion exchanger; CA; carbonic anhydrase; GPCR; G protein-coupled receptor; GPX; glutathione peroxidase; GSH; glutathione; HCQ; hydroxychloroquine; HMGB1; high mobility group box 1;
Autophagy in ischemic stroke
Keywords: 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5â²-triphosphate; BBB; blood-brain ba
Original ArticleSmac mimetics and type II interferon synergistically induce necroptosis in various cancer cell lines
Keywords: Cell death; Necroptosis; Smac; Interferon; Cancer; CI; combination index; cIAP; cellular Inhibitor of Apoptosis; FCS; fetal calf serum; IAP; Inhibitor of Apoptosis; IFN; interferon; IRF; IFN-regulatory factor; MLKL; mixed lineage kinase domain-like pseudo
Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion
Keywords: AA; Antimycin A; ALL; Allopurinol; ASK1; Apoptosis-signaling kinase 1; DCFH2-DA; 5-(6)-carboxy-2â², 7â²-dichlorodihydrofluorescein diacetate; DPI; Diphenyleneiodonium; ERK; Extracellular signal regulated kinase; H2O2; Hydrogen peroxide; JNK; c-Jun-N-ter
Cisplatin-induced necroptosis in TNFα dependent and independent pathways
Keywords: RIP; receptor-interacting protein; MLKL; mixed lineage kinase domain-like protein; CypD; cyclophilin-D; ROS; reactive oxygen species; mPTP; mitochondrial permeability transition pore; TNFα; tumor necrosis factor α; CaMKII; Ca2 +-calmodulin-dependent pr
Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)-mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy
Keywords: Autophagy; eosinophil cytolysis; eosinophilic disease; necrosis; necroptosis; non-apoptotic cell death; mixed lineage kinase-like; RIP kinase; reactive oxygen species; cfeg; Cluster of free eosinophil granules; CR3; Complement receptor 3; DPI; Diphenylene
Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma
Keywords: Regulated Cell Death; Antitumor Immunity; HMGB1; ATP; AURKA; aurora kinase A; DAMPs; damage-associated molecular patterns; GSK3β; glycogen synthase kinase 3 beta; HEK293; human embryonic kidney 293; HPDE; human pancreatic duct epithelial cell; ICD; immun
Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells
Keywords: AO; acridine orange; ATP; adenosine triphosphate; CaMK; calcium-calmodulin kinase; EGTA; ethylenebis(oxyethylenenitrilo)tetraacetic acid; IM-54; 2-(1H-Indol-3-yl)-3-pentylamino-maleimide; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazo
MLKL inhibition attenuates hypoxia-ischemia induced neuronal damage in developing brain
Keywords: ANOVA; analysis of variance; BHA; butylated hydroxyanisole; CCA; common carotid artery; Drp1; dynamin-related protein-1; HI; hypoxia-ischemia; MLKL; mixed lineage kinase domain-like protein; NAC; N-acetylcysteine; Nec-1; necrostatin 1; NSS; neurological s
Necroptosis: an alternative cell death program defending against cancer
Keywords: AIF; apoptosis-inducing factor; ALL; acute lymphoblastic leukemia; cIAP; cellular inhibitor of apoptosis protein; CLL; chronic lymphocytic leukemia; CYLD; cylindromatosis; DAMPs; Damage Associated Molecular Patterns; DCs; dendritic cells; Drp1; dynamin-re
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929
Keywords: Clnk; Necrosis; ROS; RIP3; MLKL;
Necroptosis: Pathway diversity and characteristics
Keywords: Necroptosis; RIP1; RIP3; MLKL; TNF
24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8
Keywords: 24S-OHC; 24(S)-hydroxycholesterol; ACAT1; acyl-CoA:cholesterol acyltransferase 1; AD; Alzheimer's disease; cIAP; cellular inhibitor of apoptosis protein; CYP46A1; cholesterol 24-hydroxylase; JurkatCas8â/â; caspase-8-deficient Jurkat; LDH; lactate de
Cyclophilin D and myocardial ischemia-reperfusion injury: A fresh perspective
Keywords: ANT; adenine nucleotide translocator; ATP; adenosine triphosphate; ATP5G; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); BAK; BCL2-antagonist/killer; BAX; BCL2-associated X protein; BCL-2; B cell lymphoma protein 2; C1QBP
Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells
Keywords: Apoptosis; Smac; Leukemia; Necroptosis; AML; acute myeloid leukemia; CI; combination index; cIAP; cellular inhibitor of apoptosis protein; FACS; fluorescence-activated cell-sorting analysis; FCS; fetal calf serum; FLT3; Fms-like tyrosine kinase 3; FSC/SSC
Necrosis-dependent and independent signaling of the RIP kinases in inflammation
Keywords: NF-κB; Inflammasome; TNF; Caspase 8; Fadd; MLKL
Necroptosis in health and diseases
Keywords: Necroptosis; Inflammation; RIP1; RIP3; MLKL; CYLD;
The regulation of cancer cell death and metabolism by extracellular matrix attachment
Keywords: ECM; extra cellular matrix; ROS; reactive oxygen species; PPP; pentose phosphate pathway; TCA; tricarboxylic acid; PDH; pyruvate dehydrogenase; PDK4; pyruvate dehydrogenase kinase 4; ANGPTL4; angiopoietin-like 4; PK; pyruvate kinase; TIGAR; TP53-induced g