کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10751183 | 1050307 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pexophagy is induced by increasing peroxisomal reactive oxygen species in 1â²10-phenanthroline-treated cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pexophagy is induced by increasing peroxisomal reactive oxygen species in 1â²10-phenanthroline-treated cells Pexophagy is induced by increasing peroxisomal reactive oxygen species in 1â²10-phenanthroline-treated cells](/preview/png/10751183.png)
چکیده انگلیسی
Although autophagy regulates the quality and quantity of cellular organelles, the regulatory mechanisms of peroxisomal autophagy remain largely unknown. In this study, we developed a cell-based image screening assay, and identified 1,10-phenanthroline (Phen) as a novel pexophagy inducer from chemical library screening. Treatment with Phen induces selective loss of peroxisomes but not endoplasmic reticulum and Golgi apparatus in hepatocytes. In addition, Phen increases autophagic engulfment of peroxisomes in an ATG5 dependent manner. Interestingly, treatment of Phen excessively produces peroxisomal reactive oxygen species (ROS), and inhibition of the ROS suppresses loss of peroxisome in Phen-treated cells. Taken together, these results suggest that Phen triggers pexophagy by enhancing peroxisomal ROS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 467, Issue 2, 13 November 2015, Pages 354-360
Journal: Biochemical and Biophysical Research Communications - Volume 467, Issue 2, 13 November 2015, Pages 354-360
نویسندگان
Doo Sin Jo, Dong-Jun Bae, So Jung Park, Hae Mi Seo, Han Byeol Kim, Jeong Su Oh, Jong Wook Chang, Sang-Yeob Kim, Jung-Won Shin, Dong-Hyung Cho,