کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10751615 | 1050316 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dietary vitamin D3 improves postprandial hyperglycemia in aged mice
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کلمات کلیدی
RT-PCRGSISVDROGTTGIPGLP-11,25(OH)2D3 - 1،25 (OH) 2D325(OH)D3 - 25 (OH) D325-hydroxyvitamin D3 - 25 هیدروکسی ویتامین D3[Ca2+]i - [Ca2 +] iOral glucose tolerance test - آزمون تحمل گلوکز خوراکیInsulin secretion - ترشح انسولینintracellular Ca2+ concentration - غلظت Ca2 + داخل سلولیPostprandial hyperglycemia - هیپرگلیسمی پس از فروپاشیreverse transcription-polymerase chain reaction - واکنش زنجیره ای رونویسی-پلیمراز معکوسVitamin D3 - ویتامین D3، کوله کلسیفرولgastric inhibitory polypeptide - پالپپتید مهارکننده معدهglucagon like peptide-1 - گلوکاگون مانند پپتید-1Glucose stimulated insulin secretion - گلوکز ترشح انسولین را تحریک می کندvitamin D3 receptor - گیرنده ویتامین D3
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Type 2 Diabetes is closely associated with our daily diets and has become a global health problem with an increasing number of patients. Recent observational and randomized studies on vitamin D3 suggested that higher plasma 25-hydroxyvitamin D3 [25(OH)D3] concentrations and more vitamin D3 intake are associated with lower risk of type 2 diabetes, which is characterized by postprandial hyperglycemia due to inappropriate glucose stimulated insulin secretion (GSIS) and its age-dependent increase of onset. However, rapid action of dietary vitamin D3 on the postprandial glucose profile has not been analyzed. When vitamin D3 is orally ingested in mice aged 12-14 weeks during an oral glucose tolerance test (OGTT), the serum glucose profile was not changed. In contrast, when OGTT was performed with old mice aged 30-34 weeks, the glucose profile was dramatically improved with increased insulin secretion, suggesting that orally ingested vitamin D3 potentiated GSIS in aged mice. Interestingly, there was also a significant increase in plasma GLP-1 in these aged mice. Our results suggest that orally ingested dietary vitamin D3 in aged mice improves glucose metabolism as a GLP-1 enhancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 461, Issue 1, 22 May 2015, Pages 165-171
Journal: Biochemical and Biophysical Research Communications - Volume 461, Issue 1, 22 May 2015, Pages 165-171
نویسندگان
Patricio L.M. Enciso, Lixiang Wang, Yuta Kawahara, Shohei Sakamoto, Shingo Shimada, Yukina Takeichi, Ryoichi Takayanagi, Masatoshi Nomura,