کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10751915 | 1050321 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Enterovirus 71 (EV71) is a neurotropic virus that causes hand, foot and mouth disease (HFMD), occasionally leading to death. As a member of the RAS association domain family (RASSFs), RASSF4 plays important roles in cell death, tumor development and signal transduction. However, little is known about the relationship between RASSF4 and EV71. Our study reveals for the first time that RASSF4 promotes EV71 replication and then accelerates AKT phosphorylation inhibition in EV71-infected 293T cells, suggesting that RASSF4 may be a potential new target for designing therapeutic measures to prevent and control EV71 infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 458, Issue 4, 20 March 2015, Pages 810-815
Journal: Biochemical and Biophysical Research Communications - Volume 458, Issue 4, 20 March 2015, Pages 810-815
نویسندگان
Fengfeng Zhang, Yongjuan Liu, Xiong Chen, Lanlan Dong, Bingfei Zhou, Qingqing Cheng, Song Han, Zhongchun Liu, Biwen Peng, Xiaohua He, Wanhong Liu,