کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10754667 | 1050359 | 2014 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The myokine decorin is regulated by contraction and involved in muscle hypertrophy
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کلمات کلیدی
EPSTGFαMEMSkMCTibialis Anterior - Tibialis قدامیIn vivo electroporation - الکتروپوریشن in vivointerleukin - اینترلوکینtransforming growth factor - تبدیل فاکتور رشدElectrical pulse stimulation - تحریک پالس الکتریکیSkeletal muscle cells - سلول های عضلانی اسکلتیSkeletal muscle - عضله اسکلتیIVE - من داشتمMyokines - میوکین هاexercise - ورزش
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The health-promoting effects of regular exercise are well known, and myokines may mediate some of these effects. The small leucine-rich proteoglycan decorin has been described as a myokine for some time. However, its regulation and impact on skeletal muscle has not been investigated in detail. In this study, we report decorin to be differentially expressed and released in response to muscle contraction using different approaches. Decorin is released from contracting human myotubes, and circulating decorin levels are increased in response to acute resistance exercise in humans. Moreover, decorin expression in skeletal muscle is increased in humans and mice after chronic training. Because decorin directly binds myostatin, a potent inhibitor of muscle growth, we investigated a potential function of decorin in the regulation of skeletal muscle growth. In vivo overexpression of decorin in murine skeletal muscle promoted expression of the pro-myogenic factor Mighty, which is negatively regulated by myostatin. We also found Myod1 and follistatin to be increased in response to decorin overexpression. Moreover, muscle-specific ubiquitin ligases atrogin1 and MuRF1, which are involved in atrophic pathways, were reduced by decorin overexpression. In summary, our findings suggest that decorin secreted from myotubes in response to exercise is involved in the regulation of muscle hypertrophy and hence could play a role in exercise-related restructuring processes of skeletal muscle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 450, Issue 2, 25 July 2014, Pages 1089-1094
Journal: Biochemical and Biophysical Research Communications - Volume 450, Issue 2, 25 July 2014, Pages 1089-1094
نویسندگان
Timo Kanzleiter, Michaela Rath, Sven W. Görgens, Jørgen Jensen, Daniel S. Tangen, Anders J. Kolnes, Kristoffer J. Kolnes, Sindre Lee, Jürgen Eckel, Annette Schürmann, Kristin Eckardt,