USF-1 inhibition protects against oxygen-and-glucose-deprivation-induced apoptosis via the downregulation of miR-132 in HepG2 cells

- Knockdown of USF-1 protected the HepG2 cells from oxygen and glucose deprivation (OGD)-induced apoptosis.
- A set of miRNAs were deregulated in the HepG2 cells with USF-1 siRNA treatment.
- miR-132 could inhibit the protective roles of USF-1 siRNA in the OGD-induced apoptosis in HepG2 cells.
- USF-1 could regulate miR-132 expression in HepG2 cells.
- An axis of USF-1/miR-132 inhibited OGD-induced apoptosis in HepG2 cells.