Cell-penetrating peptide-conjugated lipid nanoparticles for siRNA delivery

- Lipid derivatives of cell-penetrating peptides (CPP) were newly synthesized.
- Lipid nanoparticles modified with CPP (CPP-LNP) were designed for siRNA delivery.
- CPP-LNP entered cells by macropinocytosis and heparan sulfate-mediated endocytosis.
- Small interfering RNA encapsulated in CPP-LNP induced specific gene silencing.