Sirt2 suppresses glioma cell growth through targeting NF-κB-miR-21 axis

- Sirt2 expression is down-regulated in human glioma tissues and cell lines.
- Sirt2 regresses glioma cell growth and colony formation via inducing apoptosis.
- miR-21 is essential for the functions of Sirt2 in glioma cells.
- Sirt2 deacetylates p65 to decrease miR-21 expression.