Aquaporin 5 knockout mouse lens develops hyperglycemic cataract

- First report on the role of AQP5 in maintaining lens transparency and homeostasis.
- AQP5 regulates lens osmotic balance.
- AQP5 knockout lens exhibits osmotic swelling and develops hyperglycemic cataract.
- Glucose transporters and cotransporters cause hyperglycemia-induced water influx.
- AQP5 is critical for protecting the lens from diabetic and senile cataracts.