Redox-sensitive structural change in the A-domain of HMGB1 and its implication for the binding to cisplatin modified DNA

- The structure of the oxidized A-domain of human HMGB1 was solved.
- Phe38 ring was flipped in the oxidized structure from that in the reduced form.
- The flipped ring disables the intercalation into the cisplatinated lesions.
- The functionally relevant redox-dependent structural change was described.