کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10757701 1050396 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Suppression of Fas-mediated apoptosis via steric shielding by filovirus glycoproteins
ترجمه فارسی عنوان
سرکوب شدن آپوپتوزیس توسط فاسی از طریق محافظت استروئی توسط گلیکوپروتئین های فیلوویروس
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Apoptotic death of virus-infected cells is generally thought to be a defense mechanism to limit the spread of infectious virions by eliminating virus-producing cells in host animals. On the other hand, several viruses have been shown to have anti-apoptotic mechanisms to facilitate efficient viral replication and transmission. In this study, we found that the filovirus glycoprotein (GP) expressed on cell surfaces formed a steric shield over the Fas molecule and that GP-expressing cells showed resistance to cell death induced by a Fas agonistic antibody. These results suggest that filovirus GP-mediated steric shielding may interfere with the Fas-induced apoptotic signal transduction in infected cells and serve as an immune evasion mechanism for filoviruses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 441, Issue 4, 29 November 2013, Pages 994-998
نویسندگان
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