Crystal structure of Pseudomonas aeruginosa transcriptional regulator PA2196 bound to its operator DNA

- The structure of PA2196: dsDNA complex revealed that two dimers bind to one dsDNA.
- This binding mode is similar to that of QacR in that two dimers bind to one dsDNA.
- Residues in the α3 helix mainly interact with the base and phosphate of dsDNA.
- PA2196 undergoes large conformational changes upon DNA binding.
- The structure of PA2196: dsDNA complex help understand the recognition mechanism.