کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10757863 | 1050398 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells
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کلمات کلیدی
PI3KERK-1/2HK2HIF-1αFDGfluorodeoxyglucoseINPP4BSmall interfering RNA - RNA تداخل کوچکsiRNA - siRNALaryngeal cancer - سرطان حنجرهhypoxia-inducible factor-1α - عامل القاء شده با هیپوکسی 1αphosphatase and tensin homolog - فسفاتاز و تنسین همولوگPhosphoinositide 3-kinases - فسفوئینوزیتید 3-kinasesTumor resistance - مقاومت در برابر تومورhexokinase 2 - هگزوکیناز 2Pten - ژن PTENGlycolysis - گلیکولیز یا قندکافت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells](/preview/png/10757863.png)
چکیده انگلیسی
Inositol polyphosphate 4-phosphatase type II (INPP4B) was recently identified as a tumor resistance factor in laryngeal cancer cells. Herein, we show that INPP4B-mediated resistance is associated with increased glycolytic phenotype. INPP4B expression was induced by hypoxia and irradiation. Intriguingly, overexpression of INPP4B enhanced aerobic glycolysis. Of the glycolysis-regulatory genes, hexokinase 2 (HK2) was mainly regulated by INPP4B and this regulation was mediated through the Akt-mTOR pathway. Notably, codepletion of INPP4B and HK2 markedly sensitized radioresistant laryngeal cancer cells to irradiation or anticancer drug. Moreover, INPP4B was significantly associated with HK2 in human laryngeal cancer tissues. Therefore, these results suggest that INPP4B modulates aerobic glycolysis via HK2 regulation in radioresistant laryngeal cancer cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 440, Issue 1, 11 October 2013, Pages 137-142
Journal: Biochemical and Biophysical Research Communications - Volume 440, Issue 1, 11 October 2013, Pages 137-142
نویسندگان
Joong Won Min, Kwang Il Kim, Hyun-Ah Kim, Eun-Kyu Kim, Woo Chul Noh, Hong Bae Jeon, Dong-Hyung Cho, Jeong Su Oh, In-Chul Park, Sang-Gu Hwang, Jae-Sung Kim,