کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10758044 | 1050402 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Marine algal fucoxanthin inhibits the metastatic potential of cancer cells
ترجمه فارسی عنوان
فوکوکسانتیس جلبک دریایی پتانسیل متاستاز سلول های سرطانی را مهار می کند
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کلمات کلیدی
ملانوما، متاستاز، تهاجم، مهاجرت، رشته آتیین، چسبندگی سلولی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Metastasis is major cause of malignant cancer-associated mortality. Fucoxanthin has effect on various pharmacological activities including anti-cancer activity. However, the inhibitory effect of fucoxanthin on cancer metastasis remains unclear. Here, we show that fucoxanthin isolated from brown alga Saccharina japonica has anti-metastatic activity. To check anti-metastatic properties of fucoxanthin, in vitro models including assays for invasion, migration, actin fiber organization and cancer cell-endothelial cell interaction were used. Fucoxanthin inhibited the expression and secretion of MMP-9 which plays a critical role in tumor invasion and migration, and also suppressed invasion of highly metastatic B16-F10 melanoma cells as evidenced by transwell invasion assay. In addition, fucoxanthin diminished the expressions of the cell surface glycoprotein CD44 and CXC chemokine receptor-4 (CXCR4) which play roles in migration, invasion and cancer-endothelial cell adhesion. Fucoxanthin markedly suppressed cell migration in wound healing assay and inhibited actin fiber formation. The adhesion of B16-F10 melanoma cells to the endothelial cells was significantly inhibited by fucoxanthin. Moreover, in experimental lung metastasis in vivo assay, fucoxanthin resulted in significant reduction of tumor nodules. Taken together, we demonstrate, for the first time, that fucoxanthin suppresses metastasis of highly metastatic B16-F10 melanoma cells in vitro and in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 439, Issue 4, 4 October 2013, Pages 580-585
Journal: Biochemical and Biophysical Research Communications - Volume 439, Issue 4, 4 October 2013, Pages 580-585
نویسندگان
Tae-Wook Chung, Hee-Jung Choi, Ji-Yeon Lee, Han-Sol Jeong, Cheorl-Ho Kim, Myungsoo Joo, Jun-Yong Choi, Chang-Woo Han, So-Yeon Kim, Jae-Sue Choi, Ki-Tae Ha,