Kamolonol suppresses angiotensin II-induced stress fiber formation and cellular hypertrophy through inhibition of Rho-associated kinase 2 activity

- Kamolonol inhibits Ang II-induced stress fiber formation in H9c2 cells.
- Kamolonol suppresses Ang II-induced cellular hypertrophy in H9c2 cells.
- Kamolonol possesses a potent ROCK2 inhibitory activity.
- Kamolonol decreases Ang II-induced phosphorylation of MYPT and MLC.
- Anti-fibrotic and anti-hypertrophic effects may be due to blocking ROCK2 pathway.