[8]-Gingerol inhibits melanogenesis in murine melanoma cells through down-regulation of the MAPK and PKA signal pathways

- [8]-Gingerol suppresses cellular tyrosinase activity and decrease melanin content.
- [8]-Gingerol inhibits the expression of MC1R, MITF, tyrosinase, TRP1 and TRP2.
- [8]-Gingerol decreases intracellular RS and ROS levels in B16F10 and B16F1 cells.
- [8]-Gingerol inhibits melanogenesis by down-regulation of MAPK signaling pathway.
- [8]-Gingerol inhibits melanogenesis by down-regulation of PKA signaling pathway.