Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase

- Mitochondria dysfunction and oxidative stress are thought to cause insulin resistance.
- High fat feeding causes glucose intolerance in mice and promotes lipid oxidation in tissues.
- Increased Sod1 or Sod2 prevented obesity-induced glucose intolerance and lipid oxidation.
- No change in mitochondrial function in muscle from high fat fed mice.
- Increased Sod1, but not Sod2, reduced mitochondrial ROS and increased ATP production.