کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10758896 | 1050414 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons](/preview/png/10758896.png)
چکیده انگلیسی
The chemical inhibitor, rottlerin, and short interference RNA (siRNA) were used to inhibit or selectively knockdown PKCδ, respectively. The studies were performed using the immortalized rat mesencephalic dopaminergic cell line (N27 cells) exposed to PQ, after pre-incubation with rottlerin or transfected with PKCδ-siRNA. We observed that inhibition or knockdown of PKCδ significantly reduced PQ induced Nox1 transcript and protein levels, ROS generation and subsequent dopaminergic cell death. The results suggest that PKCδ plays a role in the regulation of Nox1-mediated oxidative stress elicited by PQ and could have a role in the pathogenesis of Parkinson's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 437, Issue 3, 2 August 2013, Pages 380-385
Journal: Biochemical and Biophysical Research Communications - Volume 437, Issue 3, 2 August 2013, Pages 380-385
نویسندگان
Ana Clara Cristóvão, Joana Barata, Goun Je, Yoon-Seong Kim,