MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN

- miR-19a/b was upregulated in multidrug-resistant gastric cancer cell lines.
- Overexpression of miR-19a/b decreased sensitivity to anticancer drugs.
- miR-19a/b accelerated the efflux of chemotherapeutics.
- miR-19a/b inhibited drug induced apoptosis. PTEN is a functional target of miR-19a/b in MDR of gastric cancer.