Preparation of quercetin and rutin-loaded ceramide liposomes and drug-releasing effect in liposome-in-hydrogel complex system

- 2-Step delivery system was prepared by incorporating ceramide liposomes into cellulose hydrogel.
- Liposome-in-hydrogel complex systems were favorable for the skin permeability than the single systems of hydrogel or liposome.
- Liposome-in-hydrogel complex systems enhanced transdermal permeation of quercetin and rutin.