کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10759565 1050429 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19
چکیده انگلیسی
The Ubiquitin Specific Protease-19 (USP19) regulates cell cycle progression and is involved in the cellular response to different types of stress, including the unfolded protein response (UPR), hypoxia and muscle atrophy. Using the unique N-terminal domain as bait in a yeast-two hybrid screen we have identified the ubiquitin ligases Seven In Absentia Homolog (SIAH)-1 and SIAH2 as binding partners of USP19. The interaction is mediated by a SIAH-consensus binding motif and promotes USP19 ubiquitylation and proteasome-dependent degradation. These findings identify USP19 as a common substrate of the SIAH ubiquitin ligases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 433, Issue 4, 19 April 2013, Pages 390-395
نویسندگان
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