Sulfuretin-induced miR-30C selectively downregulates cyclin D1 and D2 and triggers cell death in human cancer cell lines

► Sulfuretin enhances the expression of miR-30C, leading cells to apoptosis and cell cycle arrest. ► miR-30C selectively downregulates cyclin D1 and D2 but not D3. ► miR-30C mediates the tumor suppressive effects of sulfuretin in PC-3. ► Target validation analysis revealed Cyclin D1 and D2 as targets of miR-30C. ► New insights on sulfuretin as a potential anticancer drug.