Adamts1 is highly induced in rachitic bones of FGF23 transgenic mice and participates in degradation of non-mineralized bone matrix collagen

► Rachitic bone tissue of FGF23 transgenic mice shows increased Adamts1 protein. ► Adamts1 is increased in the non-mineralized part of rachitic bone. ► Adamts1 stimulate osteoblastic release of CTX fragments from de-mineralized bone.