Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice

► The HSF1 stress response pathway has been genetically implicated in glucose regulation and insulin resistance. ► HSP90 inhibitors activate the HSF1 pathway, improve glucose regulation, and augment insulin signaling. ► HSP90 inhibitors prevent diabetes in diabetic mouse models and improve glucose metabolism. ► Pharmacological support for a new therapeutic strategy for type 2 diabetes.