TNFα induced FOXP3-NFκB interaction dampens the tumor suppressor role of FOXP3 in gastric cancer cells

► FOXP3 inhibition of cell proliferation is p21-dependent under basal conditions. ► Inflammation induced by TNFα inhibits the tumor suppressor role of FOXP3. ► Interaction between p65 and FOXP3 inhibits p21 transcription activation.