The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells

► Cdh1 is required for a switch from mitosis to the endocycle during TS cell differentiation. ► Cdh1 inhibits mitotic entry of TS cell during the initiation of endocycle. ► Cdh1 regulates both in vitro and in vivo differentiation of TS cell.